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NK cells can be derived from various sources (PB, UCB, HSC, iPSC, NK cell lines) and can be engineered to express a chimeric antigen receptor (CAR) to target various surface antigens on cancer cells. These CAR‐NK cells can be used as off‐the‐shelf adoptive cellular therapy to treat patients with various malignancies.


Epithelial Tissue · Anatomy and Physiology

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Adaptive Immune Response Biology II

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Biography: Dr. Bradley Cairns received his B.S. (Honors) in Chemistry from Lewis and Clark College in Portland, Oregon in 1987. He conducted his graduate work at Stanford with Nobel Laureate Roger Kornberg Ph.D. on both signal transduction and chromatin remodeling, where he was the first to purify a chromatin remodeling complex (SWI/SNF complex.


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What is Monoclonal Antibody Therapy for Cancer? DanaFarber

Currently available CAR T-cell therapies are customized for each individual patient. They are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs.


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CAR Tcell Therapies Allogenic the Way to Go? BioProcess

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Cellular Differentiation · Anatomy and Physiology

Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells for treating haematological malignancies, there is a rapid growing interest in developing CAR-engineered NK (CAR-NK) cells for cancer therapy. Compared to CAR.


Cytophone detects cancer in earlier stages and prevents fatal disease

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The complexity of cellular biology. (a) A subset of the chemical

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Adaptive Immune Response Biology II

The main biological goal of SCNT is to reverse the differentiated state of a somatic cell, for the purpose of creating blastocysts from which embryonic stem cells (ESCs) can be derived for therapeutic cloning, or for the purpose of reproductive cloning.


Physics How to Turn an Embryo Inside Out

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